Praxis

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For my ecofeminist activist action I decided to focus on the issue of environmental gentrification, particularly in the state of Massachusetts. Currently Los Angeles, Washington, D.C., Philadelphia, Baltimore, San Diego, New York, and Chicago account for nearly half of the gentrification within the United States. Gentrification refers to “what happens when lower-income neighborhoods receive massive levels of new investment, adding amenities, raising home values and bringing in new upper-income residents” (Wiltse-Ahmad). While some my view gentrification as a positive as we’ve learned within our previous blog post it often leads to negative impacts like forced displacement and a discriminatory behaviors by people in power towards low-income individuals and people of color. As a result, plenty of individuals end up homeless or living in communities which have more environmental burdens than benefits. Sadly, Boston landed the 20th slot in the cities listed by the intensity of gentrification between the years 2000-2013. While in comparison to the top seven cities Boston is quite low it is still contributing to the problem nationwide.

Thus, I plan to start a tweeter page to share awareness within our state. I would like to educate those on the realties of gentrification and how naturally it can occur. For example, within New Bedford (where I grew up) there have been some major improvements towards the downtown area made to promote tourism. And while the number of homeless individuals have grown within the city all the local news reports many focus on is the benefits associated with the “beatification”. I would like to post pictures of local areas such as Boston, Cambridge, and Lowell communities which have been gentrified. I would also focus on highlight the number of power plants and waste facilities within the cities and towns, as well as poor health outcomes. After highlighting the negative effects associated with gentrification I plan on introducing positive movements in which these communities can learn from. Movements such as Majora Carter’s “Greening the Ghetto,” which brings in sustainable initiatives to improve the lives of those living in communities subject to environmental racism.

By making this tweeter campaign I hope to further educate those of whom don’t fully understand gentrification and how quickly it can take over communities. I would also like to relay the information on how as a community members can empower one another to work together in order to stand against tactics of gentrification. I believe my plan will be successful, because not only individuals be able to learn what gentrification truly is. The hope is they will continue to spread the word and teacher older family members who may feel powerless when faced with the threat of displacement. Ultimately, spreading awareness will make someone feel less hopeless.

 

Sources:

https://ncrc.org/study-gentrification-and-cultural-displacement-most-intense-in-americas-largest-cities-and-absent-from-many-others/

https://www.wgbh.org/news/local-news/2019/07/11/in-massachusetts-an-uneven-impact-from-rising-rents

Examining the Negative Impacts of Gentrification

 

18 thoughts on “Praxis”

  1. Hello,
    I think it is a great idea to spread awareness of gentrification. I like how you not only planned on stating the issues, but stating possible solutions. I hope in doing this, you not only show them the facts, but perhaps can obtain statements from both sides of people affected by and affecting gentrification. It would be cool to see the twitter page become essentially a resource that has not only reputable sources of facts and arguments, but primary sources taken from the people experiencing its affects as well. Perhaps you could even start a movement that encourages people to take care of each other and become less dependant on the central power and more reliant on themselves and neighbors.

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  12. Ipamorelin and Sermorelin are two of the most frequently discussed peptides in the realm of anti-aging therapy and performance
    enhancement. Though both belong to the class of
    growth hormone secretagogues, their pharmacological profiles,
    clinical uses, administration protocols, and side-effect spectrums differ
    markedly. Below is an exhaustive comparison that covers mechanism of action, dosing nuances, therapeutic benefits, safety considerations,
    and practical tips for individuals looking to combine these agents or consider them separately.

    Ipamorelin vs Sermorelin: Comprehensive Comparison and Guide

    Feature Ipamorelin Sermorelin

    Molecular Class Peptide growth hormone secretagogue
    (PHS) – ghrelin receptor agonist Growth hormone releasing hormone analogue (GHRH
    analog)

    Sequence & Size 5-mer peptide: Trp-Glu-Ala-Leu-Lys-NH2 23-aa GHRH
    analog (modified to resist enzymatic degradation)

    Primary Receptor Target Ghrelin receptor (GHS-R1a) on pituitary
    somatotrophs GHRH receptor (GHRH-R) on pituitary somatotrophs

    Mechanism of Action Mimics endogenous ghrelin;
    stimulates GH release via GHS-R1a activation, leading to downstream increases in IGF-1 and prolactin Binds to GHRH
    receptors; promotes natural GH secretion pattern with pulsatile peaks similar to physiological rhythm

    Onset & Duration of Action Rapid onset (~10–15 min post-subcutaneous injection); peak at 30–45 min, effect lasts ~2–3 h Onset slightly slower (20–30 min);
    GH pulse peaks at ~60–90 min, duration ~4–6 h

    Dosing Frequency Typically 1–3 times daily;
    common regimens: 100–200 µg before bed and/or pre-workout.
    Usually 2–3 times daily; typical doses 300–600 µg per injection.

    Administration Route Subcutaneous (SC) or intranasal
    (IN) SC only; IN not effective due to peptide size

    Half-Life ~30 min in plasma, but sustained effect due
    to receptor binding ~2–4 h with modified stability

    Side-Effect Profile Mild edema at injection site, transient flushing, increased appetite.

    Rare cases of hyperglycemia or water retention. Similar mild side effects; some
    patients experience nausea or headaches.

    Hormonal Specificity Highly selective for GH and prolactin release; minimal stimulation of
    cortisol or ACTH Also stimulates IGF-1 production but less prolactin activity

    Clinical Indications Short-term use for muscle wasting, cachexia, or as
    a research tool. Not FDA approved for any indication in the US.
    Investigational therapy for growth hormone deficiency; often used off-label for anti-aging.

    Cost & Availability Generally cheaper per dose due to shorter peptide
    chain and simpler synthesis. Slightly higher cost because
    of longer sequence and more complex manufacturing.

    Legal Status Classified as a research chemical in many jurisdictions; not approved for human use by regulatory agencies.
    Also a research compound; some countries allow therapeutic use under special permits.

    Practical Usage Scenarios

    Anti-Aging Protocols – Individuals seeking
    to boost IGF-1 and GH levels may prefer Sermorelin because it mimics
    the natural circadian rhythm of hormone release, potentially leading to more physiologic outcomes
    such as improved sleep architecture and metabolic health.

    Muscle Mass & Recovery – Ipamorelin’s rapid onset makes it popular among athletes who want a quick
    surge in GH before training or post-exercise for muscle repair.
    The modest prolactin rise may also support anabolic
    processes.

    Combination Therapy – Some practitioners recommend alternating between the two peptides on different days to leverage both
    mechanisms: use Sermorelin in the morning and Ipamorelin at night.

    This strategy can provide a broader GH pulse coverage without excessive dosing.

    Safety Monitoring – Regular bloodwork (IGF-1, fasting glucose, lipid profile) is essential
    for both agents, especially when used chronically or in higher doses.
    Keep injection sites rotated to avoid lipodystrophy.

    Book a Call

    If you are considering incorporating either Ipamorelin or Sermorelin into your health regimen and would like
    personalized guidance, it’s advisable to schedule a professional consultation. A qualified endocrinologist
    or peptide specialist can evaluate your hormone baseline, medical history, and
    specific goals before recommending a tailored dosing
    protocol. Many clinics offer virtual appointments that allow you to discuss the nuances of each peptide, potential interactions with other supplements,
    and monitoring plans.

    When booking a call:

    Prepare: Bring recent lab results (IGF-1, GH, cortisol, glucose).

    Clarify Goals: Whether you aim for anti-aging benefits, athletic performance,
    or muscle recovery.

    Discuss Risks: Understand potential side effects, contraindications, and legal status
    in your region.

    Most reputable practitioners will provide a written treatment plan and
    supply verified peptide products from GMP-certified manufacturers.
    Ensure that any purchase is compliant with local regulations to
    avoid counterfeit or contaminated substances.

    Ipamorelin Mechanism

    Ipamorelin exerts its effect by acting as an agonist at the growth hormone secretagogue receptor 1a (GHS-R1a).
    The peptide binds to this receptor located
    on somatotroph cells in the anterior pituitary. Upon binding,
    intracellular signaling cascades involving phospholipase C
    and protein kinase pathways are activated, leading to calcium influx and
    subsequent exocytosis of stored growth hormone.

    Key aspects of Ipamorelin’s mechanism include:

    Receptor Specificity – Unlike other secretagogues
    such as GHRP-6 or hexarelin, Ipamorelin has a high affinity for the ghrelin receptor while
    sparing the prolactin-stimulating pathways to a greater extent.
    This results in a more favorable side-effect profile.

    Feedback Regulation – The peptide’s action does not directly inhibit the hypothalamic release of
    growth hormone-inhibiting hormone (somatostatin).
    Instead, it stimulates GH secretion in a pulsatile manner that mimics physiological patterns, thereby reducing the risk
    of desensitization.

    IGF-1 Induction – The released GH travels to the liver and peripheral tissues, where it induces production of insulin-like growth factor
    1 (IGF-1). IGF-1 mediates many anabolic effects such as protein synthesis,
    muscle hypertrophy, and bone density improvement.

    Metabolic Effects – By increasing GH and IGF-1 levels, Ipamorelin can enhance lipolysis,
    reduce visceral fat, and improve insulin sensitivity over time.
    These metabolic benefits are often sought in anti-aging protocols.

    Safety Modulators – Because the peptide is short (only five amino acids) and lacks a large hydrophobic tail, it has lower propensity to bind non-target proteins.
    This reduces off-target activity and keeps the side-effect spectrum mild compared with longer secretagogues.

    In summary, Ipamorelin’s mechanism is tightly
    focused on stimulating growth hormone release through ghrelin receptor activation while maintaining a low side-effect burden. When used in conjunction with Sermorelin or as part of an individualized protocol, it
    can provide a versatile tool for both therapeutic and
    performance-enhancing objectives.

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  16. Primobolan is well-regarded for its ability to advertise lean muscle mass, improve energy, and enhance athletic
    performance. Unlike another steroids, it exhibits
    a relatively mild nature with decrease danger of estrogenic unwanted
    side effects and decreased androgenic exercise. Clearly, hormone substitute therapy is the commonest use of
    testosterone.
    Biking has impacted my life positively in so many various ways from the unimaginable people along the
    method in which, I’ve traveled all around the globe, seen totally different cultures, completely different everything, only a complete different world.
    That’s why, “the benefits versus the chance ought to always be considered fastidiously,”
    says Adam Rivadeneyra, MD, a sports medicine specialist with Hoag Orthopedic Institute.

    This cautious administration not solely minimizes discomfort but in addition reduces the danger of issues,
    finally contributing to higher well being outcomes for older adults.

    Abusers tend to experiment, incessantly escalating AAS dose and duration of use during their career.
    Nonetheless, some frequent principles could be deduced when examining AAS cycles
    and questioning users. Another benefit of testosterone is
    its ability to reinforce power levels and reduce fatigue.

    Whereas environmental elements play a major position in steroid dependancy,
    genetics and biology also contribute to an individual’s susceptibility.
    Sure genetic variations may make some people more susceptible to developing addictive behaviors, together with steroid habit.
    It’s necessary to notice that these half-life values are approximate and can differ relying on particular person metabolism and different elements.

    Trenbolone is a dry steroid that doesn’t aromatize or convert to estrogen; thus,
    the risk of water retention is eradicated. For this purpose, trenbolone’s thought-about the
    superior steroid in regard to aesthetics. Additionally, we find that creatine is principally used by natural bodybuilders to construct energy and muscle
    measurement. The anabolic effect of creatine is considerably much less compared to Dianabol.

    Creatine causes appreciable water retention (37, 38); subsequently,
    the mix of creatine and Dianabol will cause the physique to hold
    even more fluid.
    They are also used for replacing testosterone in males with low testosterone levels.
    Males over 40 years of age with baseline prostate-specific antigen (PSA) of more than 0.6 ng/mL ought to have
    their PSA levels measured and a prostate examination at 3 to 6 months.
    Treatment must be withheld in men with a palpable prostate nodule or prostate-specific antigen of more than four ng/mL and in sufferers at high danger of prostate malignancy with
    prostate-specific antigen of greater than 3 ng/mL.

    Science has been lagging several years behind the experimental practices of athletes.

    These practices are common to the athletic community and not for
    the medicinal functions of anabolic steroid remedy. In addition, some athletes (especially bodybuilders)
    have experimented with medication unbeknown to the medical group,
    i.e. insulin, thyroid hormones, and site-specific enhancers similar to Synthol and Esiclene to name a number of.
    Anabolic-androgenic steroids (AASs) are
    a big group of molecules including endogenously produced androgens,
    similar to testosterone, as nicely as synthetically manufactured derivatives.
    AAS use is widespread because of their ability to improve muscle growth for aesthetic purposes
    and athletes’ performance, minimizing androgenic
    effects. AAS use could be very in style and 1–3% of US inhabitants
    have been estimated to be AAS users.
    So, if it’s your first time using Nandrolone, it
    might be clever to begin out with NPP as a substitute.
    If issues go downhill early on, you can stop and have
    that NPP depart your system within days
    quite than weeks. Some guys will swear by not using Deca at anything beneath 500mg/week, even when stacking it with testosterone and different
    AAS. If you’re contemplating taking Nandrolone at
    larger doses like this, it’s better to have an excellent concept
    of how you respond and what mitigation you have to
    keep away from the worst unwanted aspect effects. Extreme customers are taking 1000g/week of Nandrolone, but only a few will find such a
    dose manageable or helpful. Of course, performance use isn’t the supposed purpose of Deca-Durabolin,
    and medical doses would not often match these used by bodybuilders.

    References:

    PedsElite

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  17. Nonetheless, the patient must take step one in analysis and therapy by admitting there is a
    potential for abuse and their willingness to suppose
    about intervention and treatment. It badly impacts cholesterol, rising the dangerous
    kind and reducing the nice type. This change can result in atherosclerosis, where arteries slim and harden. Your physician may
    help you determine if the advantages of steroid pictures outweigh the dangers.

    Taken with out medical supervision, diuretics can lead to potassium
    depletion and presumably even death. Withdrawing
    from steroids may be incredibly powerful, and the results embrace headache, tiredness, nausea, muscle ache, restlessness, poor sleep, low temper,
    low sex drive, physique dysmorphia and suicidal ideas.
    Nevertheless, steroids can be misused and abused for a spread of causes.
    In Australia, steroids could be prescribed by a health care provider for medical functions like
    treating androgen deficiency (low testosterone) or as part of
    gender-affirming therapy. But we additionally use the time period steroids
    when we’re talking about the man-made versions of these hormones.

    These will have an effect on everybody in a special
    way; many will be heavily depending on dose. There are some “common” unwanted facet
    effects that most steroid users will deal with in some unspecified time within the future, and to some stage
    of severity starting from mild to severe. It’s important to
    remember that it’s not regular for blood to seem when you’re
    injecting steroids into the muscle. If there’s
    any blood whenever you insert the needle, you hit a vein or artery rather than simply
    muscle tissue. The needle then should be eliminated, and no answer ought to be injected; as a substitute, start
    once more and find a new muscle spot that does not draw any blood.

    To get those features, you’ll must be supported with a consistent stage of heightened power, and the Feminine
    Bulking Stack doesn’t disappoint in that space.
    If you would possibly be susceptible to zits, taking steroids could produce cystic pimples, which can be extreme.

    In some instances, cystic acne can appear to resemble the dimensions of
    a golf ball beneath the pores and skin (although this is uncommon).
    This is caused by stimulation of the sebaceous glands,
    inflicting a rise in sebum production. Its perform is to naturally moisturize your pores and skin, making it delicate
    and clean.
    Proviron (mesterolone) is an anabolic steroid that was commonly used in bodybuilding’s Golden Era of the
    ’70s, generally being stacked with Dianabol. Additionally,
    we discover that creatine is mainly used by natural
    bodybuilders to build strength and muscle size. The
    anabolic impact of creatine is considerably much less in comparison to Dianabol.

    All of the above are additionally high-quality protein sources that can help with protein synthesis and
    muscle restoration. Thus, it would be acceptable to have an AI
    ready in case the nipples start to get puffy or swollen. We discover that taking an AI earlier
    than this point is often unnecessary and will solely exacerbate the already serious cardiovascular pressure that trenbolone poses.

    Trenbolone is likely considered one of the harshest anabolic steroids a bodybuilder can take, having
    devastating effects on a user’s well being, based mostly on our checks.
    Some folks use other medicine to counteract the unwanted facet effects of steroids, “cycle” their use with breaks for “recovery” or “pyramid” use by progressively rising consumption to a peak and reducing again.
    The pursuit of fitness should be about enhancing total health, bettering quality of life, and building a robust, resilient body.

    By avoiding dangerous substances like steroids and
    specializing in correct nutrition, consistent coaching, and restoration, you possibly can obtain lasting outcomes
    that benefit both your bodily and psychological well-being.

    True energy comes from perseverance, discipline, and a commitment to health—not from
    shortcuts that jeopardize your future.
    It will increase retention of nitrogen, phosphorus,
    and potassium, resulting in increased protein anabolism and a decrease within the
    catabolism of amino acids, resulting in a rise in density and hardness of
    muscle. The unwanted effects of Equipoise can include hypertension and
    excessive cholesterol, but both should be straightforward to control.
    If the individual controls water retention, which should not be hard
    to do with this steroid, hypertension shouldn’t
    be a problem baring some underlying issue. Then we now have
    ldl cholesterol, and while this isn’t an extremely unfriendly steroid to
    cholesterol it could have a adverse impact. The unwanted effects of Equipoise revolving
    round ldl cholesterol should be far much less problematic than the
    overwhelming majority of anabolic steroids, however important suppression of HDL ldl cholesterol (good
    cholesterol) is feasible.
    A brief dialog with such a person within the
    health club usually suffices to retrieve information about the local supplier.
    Though selling and shopping for of AAS is prohibited in most countries, the probabilities of being caught are negligible.
    As beforehand mentioned, Estrogen is of explicit importance and concern to those that use anabolic steroids
    by advantage of the truth that some anabolic steroids, being analogues of
    the male androgen Testosterone, are aromatizable.
    That is to say that some anabolic steroids can aromatize into Estrogen (E2).
    In truth, Estrogen levels are a paramount concern when anabolic steroid use is taken into account, as estrogenic unwanted facet effects are probably some of the focused-upon features of anabolic steroid
    use and anabolic steroid unwanted aspect effects.

    References:

    PedsElite

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  18. Consistent with the chance that heavy use of opioids influences danger for AD/ADRD is a report that dementia prevalence is elevated in prescription opioid users taking the best cumulative opioid doses (Dublin et
    al., 2015). By contrast, a population-based examine in Finland didn’t detect an association between past prescription opioid use and
    dementia (Taipale et al., 2017). However, since no studies to date have been designed to determine whether people with opiod use dysfunction are at elevated
    risk for creating AD/ADRD, studies assessing a potential affiliation are
    wanted. As A End Result Of supraphysiologic-dose AAS use might characterize a gateway to opioid use in some people (Kanayama et
    al., 2018), it additionally might be essential to determine whether polydrug use involving both of
    these substances increases risk for creating AD/ADRD.
    By distinction, supraphysiologic T (500 nM) reduces astrocyte AQP protein expression (Gu et
    al., 2003). Although the effects of orchidectomy on astrocyte AQP4 expression have yet to be described, orchidectomy decreases kidney AQP4 channel expression in male rats (Loh et al., 2017).
    Thus, it appears that eugonadal androgen ranges are needed for regular AQP4 channel expression and function. While oxidative stress reportedly upregulates AQP4 channel expression (Bi et al., 2017),
    OS also liberates zinc ion (Zn2+), an inhibitor of AQP4 channel function (Yukutake et al., 2009), from redox-sensitive
    intracellular Zn2+ sequestration websites (Kröncke and Klotz, 2009; Furuta
    et al., 2017). Amyloid plaques contain excessive Zn2+ concentrations and Zn2+ levels are high postmortem in hippocampal neurons from people with AD (Lovell et al., 1998; Suh et
    al., 2000). Accordingly, irregular androgen ranges and extra oxidative stress instantly,
    and not directly through Zn2+ mobilization, limit Aβ elimination by
    AQP4 channels. Sleep deprivation upregulates GSK3β activity (Xia et al., 2018),
    which could presumably be a basis for sleep deprivation-induced oxidative stress, Aβ, and tau-P will increase.

    Electrocardiogram was obtained and was significant for left axis deviation however otherwise no other vital findings (Figure 1).
    An echocardiogram was carried out on a subsequent visit and revealed mild left ventricular hypertrophy and mildly decreased
    proper ventricular operate. Of essential observe,
    he never had any important hypertension documented throughout his life.

    These echocardiogram findings have been suggestive of direct AAS induced biventricular results.

    In one of these research,83 one of many 20 volunteers, a person with no prior psychiatric history,
    turned so aggressive during blinded AAS administration that he was
    positioned in a seclusion room. In one other examine,81 a
    previously asymptomatic man became so aggressive on 600 milligrams per week of
    testosterone that he frightened people at his
    job and wanted to be withdrawn from the research
    for safety. In the course of this latter research, the investigators additionally administered the Cherek Level Subtraction Aggression Paradigm85 to a subgroup
    of the examine participants.86 In this protocol, the participant performed a “game” on a pc against an unseen opponent.

    The participant could press a button to accumulate points exchangeable for money (the “non-aggressive”
    response) or press one other button to subtract factors from his
    opponent (the aggressive response).
    In the Usa, an AAS is a schedule III controlled substance out there
    solely by prescription. The use of these medication is
    just legal when a medical professional prescribes them.
    Erectile dysfunction is outlined as the inability to achieve or maintain an erection enough for satisfactory sexual
    performance (189). Testosterone plays an essential
    position in practically every side of erectile operate (190) and erectile dysfunction is
    considered a suggestive symptom of testosterone deficiency (191).
    Nonetheless, not all hypogonadal men develop erectile dysfunction, and TRT generally
    results in solely a small improvement in erectile function (192).

    Though the abuse of AAS is considerably more frequent in men, its prevalence can additionally be growing in women with an estimated lifetime prevalence of 1.6%
    (Nieschlag and Vorona, 2015b). As a result, use of AAS
    has been formally banned from competitive sports activities for
    all athletes because the mid-1970s. Though there is plentiful scientific literature describing the ergogenic effects of AAS amongst male athletes (Hartgens
    and Kuipers, 2004), knowledge concerning their results in feminine athletes
    are restricted. Even extra controversial is the problem of whether
    endogenous hyperandrogenism in athletes with issues of sexual improvement (DSD), polycystic ovary syndrome and
    congenital adrenal hyperplasia provides any advantage
    in aggressive sports. We indicate that profitable stopping is simply potential
    if the person can settle for a loss in muscle mass and power.

    The purpose of the proposed evaluation is to spotlight the newest proof concerning the
    mechanisms of action of AASs and their unwanted effects on organs and lifestyle, in addition to
    suggesting that AAS misuse and abuse lead to adverse results in all body tissues and organs.
    Oxidative stress, apoptosis, and protein synthesis alteration are frequent mechanisms involved in AAS-related injury in the whole physique.
    The cardiovascular system and the reproductive system are probably the
    most regularly concerned apparatuses.
    Both medicine mildly stimulate gonadotropin and testosterone production and do not suppress spermatogenesis.

    Testosterone substitution ought to be withheld as lengthy as potential, since it interferes
    with HPG axis recovery, and prescribed provided that no further recovery of the HPG is expected.
    All customers of anabolic steroids, assuming a significant exposure, have unwanted facet effects, though nearly all of these unwanted side effects is delicate and transient and
    some go unnoticed by the abuser.

    References:

    D-bal Max user testimonials

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